Compartmentalization and Ca Buffering Are Essential for Prevention of Light-Induced Retinal Degeneration
نویسندگان
چکیده
Shirley Weiss,1 Elkana Kohn,1 Daniela Dadon,1 Ben Katz,1 Maximilian Peters,1 Mario Lebendiker,2 Mickey Kosloff,3 Nansi Jo Colley,4 and Baruch Minke1 1Department of Medical Neurobiology, Institute for Medical Research Israel-Canada (IMRIC) and the Edmond and Lily Safra Center for Brain Sciences (ELSC), Faculty of Medicine, the Hebrew University, Jerusalem 91120, Israel, 2Unit for Structural Biology, Silverman Institute for Life Sciences, The Hebrew University, Jerusalem 91904, Israel, 3Department of Biology, University of Haifa, Haifa 31905, Israel, and 4Department of Ophthalmology & Visual Sciences, Department of Genetics, UW Eye Research Institute, University of Wisconsin, Madison, Wisconsin 53792
منابع مشابه
Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.
Fly photoreceptors are polarized cells, each of which has an extended interface between its cell body and the light-signaling compartment, the rhabdomere. Upon intense illumination, rhabdomeric calcium concentration reaches millimolar levels that would be toxic if Ca(2+) diffusion between the rhabdomere and cell body was not robustly attenuated. Yet, it is not clear how such effective attenuati...
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The prototypical transient receptor potential (TRP) channel is the major light-sensitive, and Ca(2+)-permeable channel in the microvillar photoreceptors of Drosophila. TRP channels are activated following hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P₂] by the key effector enzyme phospholipase C (PLC). Mutants lacking TRP channels undergo light-dependent retinal degeneration,...
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